Senior Scientist I, Cell Line Development / Molecular Biology Job at AbbVie, San Francisco, CA

  • AbbVie
  • San Francisco, CA

Job Description

AbbVie seeks a Senior Scientist I in Cell Line Development to advance CHO cell line platforms for recombinant antibody production. This hands-on laboratory role involves designing vector constructs, engineering host cells, and optimizing protein expression through independent project execution.

Responsibilities

  • Design and test numerous vector constructs in CHO cell lines to increase monoclonal antibody titer
  • Execute transfections, screening, and clone-characterization studies with high independence
  • Operate specialized instrumentation including Octet, ViCell, CloneSelect Imager, and microfluidic platforms
  • Author technical reports, present data to leadership, and contribute scientific insights to project teams
  • Collaborate with cell culture, analytical, and bioinformatics teams to meet project milestones

Requirements

  • BS with 10+ years, MS with 8+ years, or PhD in molecular biology, cell biology, biochemistry, or related discipline
  • Proficiency with vector design software (Geneious Prime or equivalent) and DNA sequence analysis
  • Hands-on expertise in transfection, mammalian cell culture, and instrumentation (Octet, ViCell, CloneSelect Imager, Beacon)
  • Demonstrated ability to independently analyze experimental data and communicate findings to diverse audiences
  • Strong track record designing vector improvements for CHO cell expression optimization
  • Experience with flow cytometry and cell engineering techniques (CRISPR/Cas or similar)
  • Proficiency learning new techniques while managing multiple projects within defined timelines

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